Association between Placenta Malaria Parasites and Preeclampsia/Eclampsia among Parturient Mothers in Alex Ekwueme Federal University Teaching Hospital Abakaliki

In tropical countries, malaria and preeclampsia/eclampsia are common diseases of pregnancy; placenta have been implicated in the pathophysiology both disease processes. The two pathophysiologic similarities such as ischaemia, endothelial dysfunction production pro-inflammatory cytokine. Yet, there is paucity studies on association these Determining between processes may help to unravel pathogenesis preeclampsia also its prevention patient management. Objective: Determined parasitemia among parturients at Alex Ekwueme Federal University Teaching Hospital Abakaliki. Materials Methods: This was a case control study that conducted Labour wards department Obstetrics Gynaecology, Abakaliki (AEFUTHA) Mile 4 Missionary Abakaliki, comprehensive health care centre Ebonyi state. It over period 6 months 1st October 2021 31st March, 2022. cases this were developed course pregnancy, while controls parturient without preeclampsia/eclampsia. Interviewer-administered questionnaires used collect data socio-demographic characteristics, obstetrics medical histories. Histological examinations isolate plasmodium falciparum parasites from samples obtained maternal surface placenta. processed using Epi Info software. Categorical variables analyzed Mc Nemar X2 test, with p-value 0.05 considered statistically significant. Logistic regression models estimate odds ratios (OR) 95% CI conducted. Relative risk determine fetal outcomes. Results: prevalence during 2.9%. Placenta positive twenty one (21) 67 analyzed, giving 31.3% eleven (11) out 68 (normotensive) patients 16.2%. presence significantly increased developing (OR = 2.4, 1.0 - 5.4, P value 0.04). Presence mothers associated adverse pregnancy outcomes cerebrovascular accident (RR 19.2, 1.1 341.7, 0.04), DIC 10.9, 1.4 88.0, 0.02), abruptio 1.2 4.8, 0.01), pulmonary edema 2.7, 25.9, 0.03), IUGR 2.1, 4.5, 0.03) IUFD 3.8, 1.3 11.7, 0.02). NICU admission 2.6, 6.0, Low minute APGAR score 6.1, 0.02) 5th 3.0, 8.6, 0.04) neonates delivered by However, did not increase perinatal mortalities. Conclusion: There higher when compared normotensive certain morbidities. Placental either or mortality.